Granulocyte colony-stimulating factor downregulates interferon-gamma receptor expression and stimulates interleukin-6 production in activated human macrophages
Author:
Affiliation:
1. Center for Medical Biotechnologies, Immanuel Kant Baltic Federal University, Kaliningrad, Russia;
2. Laboratory for Cellular Technologies, Institute for Fundamental and Clinical Immunology, Novosibirsk, Russia
Publisher
Informa UK Limited
Subject
Cell Biology,Clinical Biochemistry,Endocrinology
Link
https://www.tandfonline.com/doi/pdf/10.1080/08977194.2019.1662418
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1. G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism
2. Human monocytes express functional receptors for granulocyte colony– stimulating factor that mediate suppression of monokines and interferon-γ
3. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
4. Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex
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