Design, Synthesis, and Biological Testing of Pyrazoline Derivatives of Combretastatin-A4: A Quest for Anticancer, Anti-Inflammatory, and Antioxidant Agents

Author:

Shringare Sadanand N.1ORCID,Chavan Hemant V.2ORCID,Kamble Narendra R.3,Tigote Radhakrishnan M.4,Bhale Pravin S.5,Mali Mukund G.6,Kadam Shuddhodan N.7,Kadam Kailas R.8,Pandhare Ganesh B.1,Khalifa Amreen N.1,Pendpale Nikita S.1,Kulkarni Makarand A.1,Bandgar Babasaheb P.1

Affiliation:

1. Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur, Maharashtra, India

2. A.S.P. College, Devrukh (Autonomous), Devrukh, Ratnagiri, Maharashtra, India

3. PDEA’s Waghire College, Saswad, Pune, Maharashtra, India

4. Dr. Babasaheb Ambedkar Marathwada University, Sub-campus Osmanabad, Osmanabad, Maharashtra, India

5. Yashwantrao Chavan Mahavidyalaya, Tuljapur, Osmanabad, Maharashtra, India

6. Advanced Material Research Laboratory, School of Chemical Sciences, Punyashlok Ahilyadevi Holkar Solapur University, Solapur, Maharashtra, India

7. Vidnyan Mahavidyalaya, Sangola, Solapur, Maharashtra, India

8. Padmashri Vikhe Patil College, Pravaranagar, Ahmednagar, Maharashtra, India

Publisher

Informa UK Limited

Subject

Materials Chemistry,Organic Chemistry,Polymers and Plastics

Reference40 articles.

1. Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum

2. Interactions of Tubulin with Potent Natural and Synthetic Analogs of the Antimitotic Agent Combretastatin: A Structure-Activity Study;Lin C.M.;Molecular Pharmacology,1988

3. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

4. Combretastatin A4 Prodrug Study of Effect on the Growth and the Microvasculature of Colorectal Liver Metastases in a Murine Model;Malcontenti-Wilson C.;Clinical Cancer Research,2001

5. Combretastatin A4 Phosphate Has Tumor Antivascular Activity in Rat and Man as Demonstrated by Dynamic Magnetic Resonance Imaging

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