Synthesis, Characterization and Molecular Docking of New Nucleosides and Schiff Bases Derived from Ampyrone as Antiviral Agents to Contain the COVID-19 Virus

Author:

Alotaibi Saad H.1,Amer Hamada H.1,Touil Nadia23,Abdel-Moneim Ahmed S.4,Soliman Mohamed M.5,Zaki Yasser H.67ORCID

Affiliation:

1. Department of Chemistry, Turabah University College, Taif University, Turabah, Taif, Saudi Arabia

2. Genomic Center for Human Pathologies (GENOPATH), Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco

3. Unité de Culture Cellulaire, CVMIT, HMI Med V, Rabat, Morocco

4. Microbiology Department, Virology Division, College of Medicine, Taif University, Turabah, Taif, Saudi Arabia

5. Department of Clinical Laboratory Sciences, Turabah University College, Taif University, Turabah, Taif, Saudi Arabia

6. Department of Chemistry, Faculty of Science, Beni-Suef University, Beni Suef, Egypt

7. Department of Chemistry, Faculty of Science and Humanity Studies at Al-Quwayiyah, Shaqra University, Al Quwayiyah, Saudi Arabia

Funder

Taif University

Publisher

Informa UK Limited

Subject

Materials Chemistry,Organic Chemistry,Polymers and Plastics

Reference36 articles.

1. World Health Organization. “WHO Director-General’s Remarks at the media briefing on 2019-nCoV on 11 February 2020,” https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (accessed March 12, 2020). Geneva (Switzerland): World Health Organization, 2020.

2. Known SARS‐CoV ‐2 infections: The tip of an important iceberg

3. A Novel Coronavirus from Patients with Pneumonia in China, 2019

4. Virus-encoded proteinases and proteolytic processing in the Nidovirales

5. Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design

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