Determination of DNA Methyltransferase 1 in Cells Using a RG108-Fluorescein Conjugate to Monitor the Fluorescent Ratio with a Microplate Reader
Author:
Affiliation:
1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China
2. Department of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China
Funder
National Natural Science Foundation of China
Special Project of Aging and Women & Children’s Health Research in Shangha
Publisher
Informa UK Limited
Subject
Electrochemistry,Biochemistry (medical),Clinical Biochemistry,Spectroscopy,Biochemistry,Analytical Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/00032719.2022.2139836
Reference29 articles.
1. DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
2. Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
3. Synthesis and Evaluation of Analogues of N-Phthaloyl-l-tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1
4. Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases
5. Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform
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1. Identification of 3-(9H-carbazol-9-yl)-2-(1,3-dioxoisoindolin-2-yl)propanoic acids as promising DNMT1 inhibitors;European Journal of Medicinal Chemistry;2024-08
2. A review on recent advances in assays for DNMT1: a promising diagnostic biomarker for multiple human cancers;The Analyst;2024
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