Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

Author:

Wallis Nadav1,Oberman Froma1,Shurrush Khriesto2,Germain Nicolas2,Greenwald Gila1,Gershon Tehila1,Pearl Talia1,Abis Giancarlo3,Singh Vikash4,Singh Amandeep5,Sharma Arun K.5,Barr Haim M.2,Ramos Andres3ORCID,Spiegelman Vladimir S.4,Yisraeli Joel K.1ORCID

Affiliation:

1. Department of Developmental Biology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel

2. The Wohl Drug Discovery Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel

3. Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, UK

4. Department of Pediatrics, Division of Pediatric Hematology/Oncology, Pennsylvania State University, College of Medicine, Hershey, PA, USA

5. Department of Pharmacology, Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA, USA

Funder

Israel Science Foundation

Israel Cancer Research Fund

National Institutes of Health National Cancer Institute

Four Diamonds Fund of the Pennsylvania State University College of Medicine

UK Medical Research Council

CRUK, MRC and the Wellcome Trust

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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