Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme-Reference-Cited by-同舟云学术

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Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme

Published:2017-11-13 Issue:1 Volume:15 Page:104-114
ISSN:1547-6286
Container-title:RNA Biology
language:en
Short-container-title:RNA Biology

Author:

Vallecillo-Viejo Isabel C.¹²,Liscovitch-Brauer Noa³,Montiel-Gonzalez Maria Fernanda¹^ORCID,Eisenberg Eli³,Rosenthal Joshua J. C.¹^ORCID

Affiliation:

1. Eugene Bell Center for Regenerative Biology and Tissue Engineering, The Marine Biological Laboratory, Woods Hole, MA, USA

2. Department of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

3. Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv, Israel

Funder

Israel Science Foundation

The United States-Israel Binational Science Foundation

HHS | National Institutes of Health

The Cystic Fibrosis Foundation

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15476286.2017.1387711

Reference44 articles.

1. A developmentally regulated activity that unwinds RNA duplexes

2. An unwinding activity that covalently modifies its double-stranded RNA substrate

3. A mammalian RNA editing enzyme

4. RNA editing and hypermutation by adenosine deamination

5. Purification of Native and Recombinant Double-Stranded RNA-Specific Adenosine Deaminases

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3. Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA;Nature Biotechnology;2024-07-12

4. Programmed RNA editing with an evolved bacterial adenosine deaminase;Nature Chemical Biology;2024-07-05

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