First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants-Reference-Cited by-同舟云学术

First-in-human study to assess the safety, pharmacokinetics, and pharmacodynamics of BMS-986141, a novel, reversible, small-molecule, PAR4 agonist in non-Japanese and Japanese healthy participants

Published:2023-07-02 Issue:1 Volume:34 Page:
ISSN:0953-7104
Container-title:Platelets
language:en
Short-container-title:Platelets

Author:

Merali Samira¹^ORCID,Wang Zhaoqing¹,Frost Charles¹,Meadows-Shropshire Stephanie¹,Hawthorne Dara¹,Yang Jing¹^ORCID,Seiffert Dietmar¹

Affiliation:

1. Research and Development, Bristol Myers Squibb, Princeton, NJ, USA

Funder

Bristol Myers Squibb

Publisher

Informa UK Limited

Subject

Hematology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/09537104.2023.2222846

Reference20 articles.

1. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

2. Cardiovascular diseases (CVDs): World Health Organization (WHO). https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).

3. Recurrent ischemic stroke: strategies for prevention;Oza R;Am Fam Physician,2017

4. Using PAR4 Inhibition as an Anti-Thrombotic Approach: Why, How, and When?

5. Novel Antithrombotic Drugs on the Horizon

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