Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

Author:

Deland Lily12ORCID,Keane Simon3ORCID,Olsson Bontell Thomas45,Sjögren Helene1,Fagman Henrik4ORCID,Øra Ingrid67ORCID,De La Cuesta Esther8,Tisell Magnus9,Nilsson Jonas A10ORCID,Ejeskär Katarina3,Sabel Magnus1112ORCID,Abel Frida12ORCID

Affiliation:

1. Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden

2. Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

3. Translational Medicine, School of Health Sciences, University of Skövde, Skövde, Sweden

4. Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden

5. Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

6. Department of Clinical Sciences, Lund University Hospital, Lund, Sweden

7. HOPE/ITCC Phase I/II Trial Unit, Pediatric Oncology, Karolinska Hospital, Stockholm, Sweden

8. Pharmaceuticals, Global Medical Affairs – Oncology, Bayer U.S., Whippany, USA

9. Department of Clinical Neuroscience and Rehabilitation, Sahlgrenska University Hospital, Gothenburg, Sweden

10. Sahlgrenska Cancer Center, Department of Laboratory Medicine Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

11. Childhood Cancer Centre, Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden

12. Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Funder

the Swedish Cancer Society

Barncancerfonden

Cancerfonden

Sahlgrenska Universitetssjukhuset

Publisher

Informa UK Limited

Subject

Cancer Research,Pharmacology,Oncology,Molecular Medicine

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