NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma

Author:

Kubala Jaclyn M.123,Laursen Kristian B.1,Schreiner Ryan4,Williams Ryan M.25,van der Mijn Johannes C.1,Crowley Michael J.6,Mongan Nigel P.17,Nanus David M.389,Heller Daniel A.126,Gudas Lorraine J.139ORCID

Affiliation:

1. Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA

2. Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

3. Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

4. Division of Regenerative Medicine Research, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

5. Department of Biomedical Engineering, the City College of New York, New York, NY, USA

6. Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA

7. Faculty of Medicine and Health Sciences, Center for Cancer Sciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK

8. Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

9. Department of Urology; New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA

Funder

National Institutes of Health

National institute of diabetes and digestive and kidney diseases

Publisher

Informa UK Limited

Subject

Cancer Research,Pharmacology,Oncology,Molecular Medicine

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