Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models

Author:

Kaistha Brajesh P.1,Kar Gozde1,Dannhorn Andreas2,Watkins Amanda1,Opoku-Ansah Grace1,Ilieva Kristina13,Mullins Stefanie14,Anderton Judith1,Galvani Elena1,Garcon Fabien1,Lapointe Jean-Martin5,Brown Lee2,Hair James1,Slidel Tim1,Luheshi Nadia1,Ryan Kelli1,Hardaker Elizabeth1,Dovedi Simon1,Kumar Rakesh6,Wilkinson Robert W.1,Hammond Scott A.6,Eyles Jim1ORCID

Affiliation:

1. Oncology R & D, AstraZeneca, Cambridge, UK

2. Imaging Sciences, AstraZeneca, Cambridge, UK

3. Immunooncology, MorphoSys AG, Planegg, Germany

4. Translational Science, F-Star, Cambridge, UK

5. Oncology Safety Pathology, AstraZeneca, Cambridge, UK

6. Oncology R & D, AstraZeneca, Gaithersburg, MD, USA

Funder

no funding associated with the work

Publisher

Informa UK Limited

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