CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients
Author:
Affiliation:
1. Morphotek Inc., Exton, PA, USA
2. Thoracic and GI Oncology Branch, Head, Thoracic and Solid Tumor Immunotherapy Section, National Cancer Institute, Bethesda, Maryland, USA
Publisher
Informa UK Limited
Subject
Cancer Research,Pharmacology,Oncology,Molecular Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/15384047.2018.1449614
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1. Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125
2. MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
3. Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125)
4. Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement
5. FCGR2A and FCGR3A Genotypes Correlate with Farletuzumab Response in Patients with First-Relapsed Ovarian Cancer Exhibiting Low CA125
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1. MUC1 and MUC16: critical for immune modulation in cancer therapeutics;Frontiers in Immunology;2024-02-01
2. NAV‐003, a bispecific antibody targeting a unique mesothelin epitope and CD3ε with improved cytotoxicity against humoral immunosuppressed tumors;European Journal of Immunology;2023-06-20
3. NAV-001, a high-efficacy antibody-drug conjugate targeting mesothelin with improved delivery of a potent payload by counteracting MUC16/CA125 inhibitory effects;PLOS ONE;2023-05-17
4. Prognostic Value of Elevated Pre-treatment Serum CA-125 in Epithelial Ovarian Cancer: A Meta-Analysis;Frontiers in Oncology;2022-04-07
5. Block‑Removed Immunoglobulin Technology to enhance rituximab effector function by counteracting CA125‑mediated immunosuppression;Oncology Letters;2021-11-02
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