The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib-Reference-Cited by-同舟云学术

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib

Published:2017-12-08 Issue:2 Volume:19 Page:132-137
ISSN:1538-4047
Container-title:Cancer Biology & Therapy
language:en
Short-container-title:Cancer Biology & Therapy

Author:

Booth Laurence¹,Roberts Jane L.¹,Poklepovic Andrew²,Kirkwood John³,Sander Cindy³^ORCID,Avogadri-Connors Francesca⁴,Cutler Jr Richard E.⁴,Lalani Alshad S.⁴,Dent Paul¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA

2. Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA

3. University of Pittsburgh Cancer Institute, Melanoma and Skin Cancer Program, Hillman Cancer Research Pavilion Laboratory L1.32c, Pittsburgh, PA, USA

4. Puma Biotechnology Inc. 1880 Wilshire Blvd, Los Angeles, CA, USA

Funder

HHS | NIH | National Cancer Institute (NCI)

Publisher

Informa UK Limited

Subject

Cancer Research,Pharmacology,Oncology,Molecular Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/15384047.2017.1394556

Reference10 articles.

1. The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling

2. EGFR Family Members’ Regulation of Autophagy Is at a Crossroads of Cell Survival and Death in Cancer