Inhibition of Cdc42–intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth

Author:

Aguilar Byron J.1ORCID,Zhao Yaxue2,Zhou Huchen2,Huo Shouquan3,Chen Yan-Hua1,Lu Qun14

Affiliation:

1. Department of Anatomy & Cell Biology, The Brody School of Medicine, East Carolina University, Greenville, NC, USA

2. State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China

3. Department of Chemistry, Harriot College of Arts and Sciences, East Carolina University, Greenville, NC, USA

4. The Harriet and John Wooten Laboratory for Alzheimer’s and Neurodegenerative Diseases Research, The Brody School of Medicine, East Carolina University, Greenville, NC, USA

Funder

National Cancer Institute

National Natural Science Foundation of China

Ministry of Science and Technology of China

E-Institutes of Shanghai Universities Chemical Biology Division

Alzheimer's Association

Publisher

Informa UK Limited

Subject

Cancer Research,Pharmacology,Oncology,Molecular Medicine

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