Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice

Author:

Mainz Laura12,Sarhan Mohamed A. F. E.12,Roth Sabine1,Sauer Ursula12,Kalogirou Charis3,Eckstein Markus4,Gerhard-Hartmann Elena12,Seibert Helen-Desiree12,Voelker Hans-Ulrich5ORCID,Geppert Carol4,Rosenwald Andreas12,Eilers Martin6,Schulze Almut7ORCID,Diefenbacher Markus6,Rosenfeldt Mathias T.12ORCID

Affiliation:

1. Institute of Pathology, Julius-Maximilians-University of Würzburg, Würzburg, Germany

2. Comprehensive Cancer Center Mainfranke, Julius-Maximilians-University of Würzburg, Würzburg, Germany

3. Department of Urology and Pediatric Urology, Julius-Maximilians-University of Würzburg, Würzburg, Germany

4. Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

5. Department of Pathology, Leopoldina Medizinisches Versorgungszentrum, Schweinfurt, Germany

6. Biocenter, Department of Biochemistry and Molecular Biology, Julius-Maximilians-University of Würzburg, Germany

7. Division of Metabolism and Microenvironment, Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Germany

Funder

funding

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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