Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance

Author:

Zhang Xiaozhen12ORCID,Lao Mengyi12,Yang Hanshen12,Sun Kang12,Dong Yunfei3,He Lihong12,Jiang Xinchi34,Wu Honghui3,Jiang Yangwei5,Li Muchun12,Ying Honggang12,Liu Xinyuan12,Xu Jian12,Chen Yan12,Zhang Hanjia12,Zhou Ruhong56,Gao Jianqing3478,Bai Xueli128ORCID,Liang Tingbo128ORCID

Affiliation:

1. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

2. Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, PR China

4. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China

5. Institute of Quantitative Biology, College of Life Sciences, and Shanghai Institute for Advanced Study, Zhejiang University, Hangzhou, Zhejiang, China

6. Department of Chemistry, Columbia University, New York, NY, USA

7. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China

8. Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China

Funder

National Key Research and Development Program

National Natural Science Foundation of China

Key Research and Development Program of Zhejiang Province

Natural Science Foundation of Zhejiang Province

Publisher

Informa UK Limited

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