International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Author:

Chen Xin1ORCID,Tsvetkov Andrey S.2,Shen Han-Ming3,Isidoro Ciro4,Ktistakis Nicholas T.5,Linkermann Andreas67,Koopman Werner J.H.89,Simon Hans-Uwe1011ORCID,Galluzzi Lorenzo121314,Luo Shouqing15,Xu Daqian16,Gu Wei17,Peulen Olivier18,Cai Qian19,Rubinsztein David C.2021ORCID,Chi Jen-Tsan22,Zhang Donna D.23,Li Changfeng24,Toyokuni Shinya2526,Liu Jinbao27,Roh Jong-Lyel28,Dai Enyong29,Juhasz Gabor3031,Liu Wei32,Zhang Jianhua33,Yang Minghua3435,Liu Jiao36,Zhu Ling-Qiang37,Zou Weiping38,Piacentini Mauro3940,Ding Wen-Xing41,Yue Zhenyu42,Xie Yangchun43,Petersen Morten44,Gewirtz David A.45ORCID,Mandell Michael A.46,Chu Charleen T.47,Sinha Debasish48,Eftekharpour Eftekhar4950,Zhivotovsky Boris515253,Besteiro Sébastien5455,Gabrilovich Dmitry I.56,Kim Do-Hyung57,Kagan Valerian E.58,Bayir Hülya59,Chen Guang-Chao60,Ayton Scott61,Lünemann Jan D.62,Komatsu Masaaki63,Krautwald Stefan64,Loos Ben65,Baehrecke Eric H.66,Wang Jiayi676869,Lane Jon D.70,Sadoshima Junichi71,Yang Wan Seok72,Gao Minghui73,Münz Christian74,Thumm Michael75,Kampmann Martin7677,Yu Di7879,Lipinski Marta M.80ORCID,Jones Jace W.81,Jiang Xuejun82,Zeh Herbert J.83,Kang Rui83,Klionsky Daniel J.84ORCID,Kroemer Guido855055ORCID,Tang Daolin83

Affiliation:

1. Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China

2. Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, USA

3. Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China

4. Department of Health Sciences, University of Piemonte Orientale, Novara, Italy

5. Babraham Institute, Cambridge, UK

6. Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany

7. Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA

8. Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

9. Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands

10. Institute of Pharmacology, University of Bern, Bern, Switzerland

11. Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany

12. Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA

13. Sandra and Edward Meyer Cancer Center, New York, NY, USA

14. Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA

15. Peninsula Medical School, University of Plymouth, Plymouth, UK

16. Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China

17. Institute for Cancer Genetics, and Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA

18. Metastasis Research Laboratory, GIGA Cancer-University of Liège, Liège, Belgium

19. Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA

20. Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK

21. UK Dementia Research Institute, University of Cambridge, Cambridge, UK

22. Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA

23. Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA

24. Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China

25. Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan

26. Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan

27. Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China

28. Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea

29. The Second Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China

30. Biological Research Center, Institute of Genetics, Szeged, Hungary

31. Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary

32. Department of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China

33. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA

34. Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China

35. Hunan Clinical Research Center of Pediatric Cancer, Changsha, China

36. DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

37. Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

38. Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, USA

39. Department of Biology, University of Rome “Tor Vergata”, Rome, Italy

40. National Institute for Infectious Diseases IRCCS “Lazzaro Spallanzani”, Rome, Italy

41. Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA

42. Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

43. Department of Oncology, Central South University, Changsha, Hunan, China

44. Functional genomics, Department of Biology, Copenhagen University, Denmark

45. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA

46. Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, USA

47. Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

48. Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA; Wilmer Eye lnstitute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

49. Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada

50. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer, Villejuif, France; Gustave Roussy Cancer, Villejuif, France

51. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Europe

52. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia

53. Engelhardt Institute of Molecular Biology, Moscow, Russia

54. LPHI, University Montpellier, CNRS, Montpellier, France

55. Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

56. AstraZeneca, Early Oncology R&D, Gaithersburg, MD, USA

57. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA

58. Department of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA

59. Department of Pediatrics, Columbia University, New York, USA

60. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

61. Florey Institute, University of Melbourne, Parkville, Australia

62. Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany

63. Department of Physiology, Juntendo University School of Medicine, Bunkyo-ku Tokyo, Japan

64. Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany

65. Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa

66. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA

67. Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

68. Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

69. College of Medical Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

70. School of Biochemistry, University of Bristol, Bristol, UK

71. Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, USA

72. Department of Biological Sciences, St. John’s University, New York City, NY, USA

73. The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China

74. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

75. Department of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany

76. Department of Biochemistry & Biophysics, University of California, San Francisco, USA

77. Institute for Neurodegenerative Diseases, University of California, San Francisco, USA

78. Faculty of Medicine, Frazer Institute, University of Queensland, Brisbane, Australia

79. Faculty of Medicine, Ian Frazer Centre for Children’s Immunotherapy Research, Child Health Research Centre, University of Queensland, Brisbane, Australia

80. Department of Anesthesiology & Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA

81. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA

82. Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

83. Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA

84. Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

85. Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France

Funder

National Natural Science Foundation of China

Publisher

Informa UK Limited

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