Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense

Author:

Choi Eun-Ji12,Oh Hyun-Taek13,Lee Seon-Hyeong4,Zhang Chen-Song5,Li Mengqi5,Kim Soo-Youl4,Park Sunghyouk6,Chang Tong-Shin1,Lee Byung-Hoon1,Lin Sheng-Cai5,Jeon Sang-Min123ORCID

Affiliation:

1. Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Korea

2. College of Pharmacy, Ajou University, Suwon, Gyeonggi-do, Korea

3. Department of BioHealth Regulatory Science, Graduate School of Ajou University, Suwon, Gyeonggi-do, Korea

4. Division of Cancer Biology, Research Institute, National Cancer Center, Goyang, Gyeonggi-do, Korea

5. State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, Xiamen, China

6. Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul, Korea

Funder

New Faculty Startup Fund from Seoul National University

Basic Science Research Program through the National Research Foundation of Korea

Ministry of Education

National R&D Program for Cancer Control

Ministry of Health & Welfare

Republic of Korea

Korea Health Technology R&D Project through the Korea Health Industry Development Institute

Ministry of Health & Welfare, Republic of Korea

Ministry of Food and Drug Safety

Publisher

Informa UK Limited

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