HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport
Author:
Affiliation:
1. Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
2. Department of Oncology, Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou, China
Funder
National Natural Science Foundation for Distinguished Young Scholar of China
National Natural Science Foundation of China
Public Projects of Zhejiang Province
Publisher
Informa UK Limited
Subject
Cell Biology,Molecular Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/15548627.2018.1501134
Reference47 articles.
1. Acquired tumor cell resistance to sunitinib causes resistance in a HT-29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature
2. Sunitinib: From Rational Design to Clinical Efficacy
3. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA
4. Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma
5. Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism
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