ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

Author:

Keulers Tom G.1,Koch Alexander2ORCID,van Gisbergen Marike W.3ORCID,Barbeau Lydie M.O.1,Zonneveld Marijke I.1ORCID,de Jong Monique C.4ORCID,Savelkouls Kim G.M.1,Wanders Roel G.5,Bussink Johan6ORCID,Melotte Veerle2ORCID,Rouschop Kasper M.A.1ORCID

Affiliation:

1. Department of Radiotherapy, Grow - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

2. Department of Pathology, Grow - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands

3. The M-Lab, Department of Precision Medicine, Grow – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

4. Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

5. MAASTRO Clinic, Maastricht, Netherlands

6. Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands

Funder

Dutch Cancer Society

worldwide cancer research

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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