Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway

Author:

Xing Yanhong1,Wei Xiangqing2,Liu Yucheng1,Wang Meng-Meng3,Sui Zhongheng1,Wang Xinyan1,Zhu Wucheng1,Wu Mengmei1,Lu Chen1,Fei Yuan-Hui1,Jiang Yi1,Zhang Yang1,Wang Yuqing4,Guo Feng5,Cao Jun-Li1,Qi Jiansong16,Wang Wuyang1ORCID

Affiliation:

1. Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, 209 Tongshan Rd, Xuzhou, Jiangsu 221004, China

2. Department of Anesthesiology, the Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226006, China

3. Department of Otolaryngology and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110122, China

4. Department of Medicine and Biosystemic Science, Faculty of Medicine, Kyushu University, Fukuoka, 8128582, Japan

5. Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, China

6. Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada

Funder

supported

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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