Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Author:

Tong Benjamin Chun-Kit1ORCID,Wu Aston Jiaxi1,Huang Alexis Shiying1,Dong Rui2,Malampati Sandeep1,Iyaswamy Ashok1ORCID,Krishnamoorthi Senthilkumar1,Sreenivasmurthy Sravan Gopalkrishnashetty1,Zhu Zhou1,Su Chengfu1,Liu Jia1,Song Juxian3ORCID,Lu Jia-Hong4ORCID,Tan Jieqiong5,Pan Weidong6ORCID,Li Min1ORCID,Cheung King-Ho1ORCID

Affiliation:

1. School of Chinese Medicine and Mr. And Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, Hong Kong Baptist University, Hong Kong, China

2. School of Biomedical Sciences, University of Hong Kong, Hong Kong, China

3. Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China

4. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China

5. Center for Medical Genetics and Hunan, Key Laboratory of Animal Model for Human Diseases, School of Life Sciences, Central South University, Changsha, Hunan 410078, China

6. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, China

Funder

Hong Kong Baptist University

Guangdong Natural Science Foundation

Health and Medical Research Fund

Research Grants Council, University Grants Committee

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

Reference62 articles.

1. Alzheimer’s Disease International. World Alzheimer report 2019: attitudes to dementia. Alzheimer’s Disease International London, UK; 2019.

2. A Hundred Years of Alzheimer's Disease Research

3. Autophagy failure in Alzheimer's disease—locating the primary defect

4. Autophagy: from phenomenology to molecular understanding in less than a decade

5. Development by Self-Digestion

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