Lipophagy confers a key metabolic advantage that ensures protective CD8A T-cell responses against HIV-1-Reference-Cited by-同舟云学术

Lipophagy confers a key metabolic advantage that ensures protective CD8A T-cell responses against HIV-1

Published:2021-01-18 Issue:11 Volume:17 Page:3408-3423
ISSN:1554-8627
Container-title:Autophagy
language:en
Short-container-title:Autophagy

Author:

Loucif Hamza¹^ORCID,Dagenais-Lussier Xavier¹,Beji Cherifa¹,Cassin Léna¹,Jrade Hani²³⁴,Tellitchenko Roman¹,Routy Jean-Pierre⁵,Olagnier David⁶,van Grevenynghe Julien¹

Affiliation:

1. Institut National de la Recherche Scientifique (INRS)-Centre Armand-Frappier Santé Biotechnologie

2. The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada

3. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada

4. Ottawa Institute of Systems Biology, Ottawa, ON, Canada

5. Chronic Viral Illness Service and Division of Hematology, McGill University Health Centre, Glen Site, Montreal, QC, Canada

6. Department of Biomedicine, Research Center for Innate Immunology, Aarhus University, Aarhus C, Denmark

Funder

Canadian Network for Research and Innovation in Machining Technology

Natural Sciences and Engineering Research Council of Canada

Fonds de Recherche du Québec - Santé

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15548627.2021.1874134

Reference56 articles.

1. Predicting the Impact of CD8+ T Cell Polyfunctionality on HIV Disease Progression

2. Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection

3. Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

4. Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

5. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

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