METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Author:

Song Huiwen12,Feng Xing13ORCID,Zhang Heng4,Luo Yunmei1,Huang Juan1,Lin Meihua5,Jin Junfei6,Ding Xue7,Wu Shujing8,Huang He49,Yu Tian10,Zhang Mukun11,Hong Haiou11,Yao Shihua12,Zhao Yongxiang13,Zhang Zhiyong114ORCID

Affiliation:

1. Longju Medical Research Center; Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, China

2. Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

3. Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA

4. Department of Histology and Embryology, Xiang Ya School of Medicine, Central South University, Changsha, China

5. Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China

6. Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, China

7. Department of Cardiology; the First Affiliated Hospital, Harbin Medical University, Harbin, China

8. Department of Cardiology, The ChengGong Hospital Affiliated to Xiamen University, Xiamen, China

9. Digestive Cancer Laboratory, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China

10. Department of Anesthesia, Affiliated Hospital of Zunyi Medical University, Zunyi, China

11. Health Management Center, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Hefei, China

12. Department of Thoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China

13. National Center for International Research of Biological Targeting Diagnosis and Therapy (Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research), Guangxi Medical University, Nanning, China

14. Department of Surgery; Robert-Wood-Johnson Medical School University Hospital, Rutgers University, State University of New Jersey, New Brunswick, NJ USA

Funder

Shanghai Research Project

Shanghai University of Medicine&Health Sciences Seed Fund

Shanghai Medical Key Specialty Construction Projects

key programs of Shanghai Municipal Health and Family Planning Commission

National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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