The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux-Reference-Cited by-同舟云学术

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

Published:2015-08-03 Issue:8 Volume:11 Page:1373-1388
ISSN:1554-8627
Container-title:Autophagy
language:en
Short-container-title:Autophagy

Author:

Wiersma Valerie R¹,de Bruyn Marco²,Wei Yunwei¹³,van Ginkel Robert J¹,Hirashima Mitsuomi⁴⁵,Niki Toshiro⁴⁵,Nishi Nozomu⁶,Zhou Jin⁷,Pouwels Simon D⁸,Samplonius Douwe F¹,Nijman Hans W²,Eggleton Paul⁹,Helfrich Wijnand¹⁷,Bremer Edwin¹⁹

Affiliation:

1. University of Groningen; University Medical Center Groningen; Department of Surgery; Translational Surgical Oncology; Groningen, The Netherlands

2. University of Groningen; University Medical Center Groningen; Department of Gynecology & Obstetrics; Groningen, The Netherlands

3. Oncological and Endoscopic Surgery Department; First Affiliated Hospital of Harbin Medical University; China

4. Department of Immunology & Immunopathology; Kagawa University Faculty of Medicine; Kagawa, Japan

5. GalPharma Co., Ltd.; Kagawa, Japan

6. Division of Research Instrument and Equipment; Life Science Research Center; Kagawa University; Kagawa, Japan

7. Health Ministry Key Lab of Cell Transplantation; Heilongjiang Institute of Hematology and Oncology; Department of Hematology; First Affiliated Hospital; Harbin Medical University; Harbin, China

8. University of Groningen; University Medical Center Groningen; Experimental pulmonology and inflammation research; GRIAC Research Institute; Department of Pathology and Medical Biology; Groningen

9. Exeter University Medical School; Devon, UK

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15548627.2015.1063767

Reference53 articles.

1. KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers

2. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

3. Ras in digestive oncology

4. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

5. K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc

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