Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway-Reference-Cited by-同舟云学术

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

Published:2020-05-20 Issue:7 Volume:17 Page:1592-1613
ISSN:1554-8627
Container-title:Autophagy
language:en
Short-container-title:Autophagy

Author:

Zheng Zu-Guo¹,Zhu Si-Tong¹²,Cheng Hui-Min¹,Zhang Xin¹,Cheng Gang³,Thu Pyone Myat¹,Wang Supeng Perry⁴,Li Hui-Jun¹,Ding Ming¹,Qiang Lei¹,Chen Xiao-Wei⁵,Zhong Qing⁶,Li Ping¹,Xu Xiaojun¹²

Affiliation:

1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China

2. Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, Jiangsu, China

3. Beijing Kanglisheng Pharmaceutical Technology Development Co., Ltd, Beijing, China

4. Appleby College, Oakville, Ontario, Canada

5. State Key Laboratory of Membrane Biology, Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China

6. School of Medicine, Shanghai Jiaotong University, Shanghai, China

Funder

Ministry of Science and Technology

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

the Ministry of Science and Technology of China

Innovative Research Group Project of the National Natural Science Foundation of China

National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program“

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15548627.2020.1757955

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