NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation

Author:

Cai Cui-Zan1,Yang Chuanbin2ORCID,Zhuang Xu-Xu1,Yuan Ning-Ning1,Wu Ming-Yue1,Tan Jie-Qiong3,Song Ju-Xian24ORCID,Cheung King-Ho2,Su Huanxing1,Wang Yi-Tao1,Tang Bei-Sha5,Behrends Christian6ORCID,Durairajan Siva Sundara Kumar27ORCID,Yue Zhenyu8ORCID,Li Min2ORCID,Lu Jia-Hong1ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China

2. Mr. And Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China

3. Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China

4. Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China

5. Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China

6. Munich Cluster for Systems Neurology (Synergy), Ludwig-Maximilians-Universität München, München, Germany

7. Division of Mycobiology and Neurodegenerative Disease Research, Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India

8. Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Funder

Ministry of Science and Technology of the People’s Republic of China

National Natural Science Foundation of China

FDCT

Universidade de Macau

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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