Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Author:

Hernández-Tiedra Sonia12,Fabriàs Gemma3,Dávila David12,Salanueva Íñigo J.1,Casas Josefina3,Montes L. Ruth4,Antón Zuriñe4,García-Taboada Elena1,Salazar-Roa María1,Lorente Mar12,Nylandsted Jesper5,Armstrong Jane67,López-Valero Israel12,McKee Christopher S.6,Serrano-Puebla Ana18,García-López Roberto1,González-Martínez José12,Abad José L.3,Hanada Kentaro9,Boya Patricia8,Goñi Félix4,Guzmán Manuel110,Lovat Penny6,Jäättelä Marja5,Alonso Alicia4,Velasco Guillermo12

Affiliation:

1. Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain

2. Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain

3. Research Unit on BioActive Molecules (RUBAM), Departments of Biomedicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain

4. Biofisika Institute (UPV/EHU, CSIC), and Departamento de Bioquímica, Universidad del País Vasco, Barrio Sarriena s/n, Leioa, Spain

5. Unit of Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center (DCRC), Copenhagen, Denmark

6. Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK

7. Faculty of Applied Sciences, University of Sunderland, Sunderland, UK

8. Departament of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

9. Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan

10. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid, Spain

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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