KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function

Author:

Wang Li-Hong12,Wei Sen2,Yuan Ye2,Zhong Ming-Jun3,Wang Jiao2,Yan Ze-Xuan2,Zhou Kai4,Luo Tao2,Liang Li1,Bian Xiu-Wu2ORCID

Affiliation:

1. Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China

2. Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China

3. Institute of Rare Diseases, West China Hospital of Sichuan University, Chengdu 610000, China

4. Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China

Funder

General Project of Chongqing Natural Science Foundation

Special project of Scientific and Technological Innovation Capability Improvement of Army Military Medical University

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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