HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC-Reference-Cited by-同舟云学术

HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC

Published:2018-03-21 Issue: Volume: Page:1-14
ISSN:1554-8627
Container-title:Autophagy
language:en
Short-container-title:Autophagy

Author:

Han Jie¹,Goldstein Leslie A.¹,Hou Wen¹,Chatterjee Suman²,Burns Timothy F.²,Rabinowich Hannah¹

Affiliation:

1. Department of Pathology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

2. Department of Medicine, Division of Hematology-Oncology, University of Pittsburgh School of Medicine and The University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

Funder

US Department of Veterans Affairs

Department of Defense

NIH

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15548627.2018.1434471

Reference60 articles.

1. HSP90 and the chaperoning of cancer

2. Inhibiting HSP90 to Treat Cancer: A Strategy in Evolution

3. Inhibition of HSP90 molecular chaperones: moving into the clinic

4. Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib

5. Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer

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