Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Author:

Hou Xu1,Fiesel Fabienne C.12,Truban Dominika1,Castanedes Casey Monica1,Lin Wen-lang1,Soto Alexandra I.1,Tacik Pawel1,Rousseau Linda G.1,Diehl Nancy N.3,Heckman Michael G.3,Lorenzo-Betancor Oswaldo1,Ferrer Isidre45ORCID,Arbelo José M.6,Steele John C.7,Farrer Matthew J.8,Cornejo-Olivas Mario910,Torres Luis11,Mata Ignacio F.1213,Graff-Radford Neill R.14,Wszolek Zbigniew K.14,Ross Owen A.12,Murray Melissa E.12,Dickson Dennis W.12,Springer Wolfdieter12

Affiliation:

1. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

2. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA

3. Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA

4. Institut de Neuropatologia, Servei d’Anatomia Patològica, Hospital Universitari de Bellvitge, Hospitalet del Llobregat, Barcelona, Spain

5. CIBERNED, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain

6. Parkinson’s and Movement Disorders Unit, Department of Neurology, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain

7. Micronesian Health Study II, Tamuning, Guam

8. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

9. Northern Pacific Global Health Research Fellows Training Consortium, Bethesda, MD, USA

10. Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru

11. Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru

12. Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA, USA

13. Department of Neurology, University of Washington, Seattle, WA, USA

14. Department of Neurology, Mayo Clinic, Jacksonville, FL, USA

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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