Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

Author:

Beccari Sol12ORCID,Sierra-Torre Virginia12ORCID,Valero Jorge123ORCID,Pereira-Iglesias Marta12,García-Zaballa Mikel12,Soria Federico N.124ORCID,De Las Heras-Garcia Laura12,Carretero-Guillen Alejandro1ORCID,Capetillo-Zarate Estibaliz1245ORCID,Domercq Maria12ORCID,Huguet Paloma R.12,Ramonet David6,Osman Ahmed7,Han Wei7,Dominguez Cecilia7,Faust Travis E.8ORCID,Touzani Omar9,Pampliega Olatz12ORCID,Boya Patricia1011,Schafer Dorothy8ORCID,Mariño Guillermo1112,Canet-Soulas Emmanuelle6ORCID,Blomgren Klas713,Plaza-Zabala Ainhoa114,Sierra Amanda124ORCID

Affiliation:

1. Glial Cell Biology Labb, Department of Biochemistry and Molecular Biology, Achucarro Basque Center for Neuroscience, 48940, Leioa, Bizkaia, Spain

2. Department of Neuroscience, University of the Basque Country UPV/EHU, 48940, Leioa, Bizkaia, Spain

3. Neural Plasticity and Neurorepair Group, Laboratory of Neuronal Plasticity and Neurorepair, Institute for Neuroscience of Castilla y León (INCyL), and Institute for Biomedical Research of Salamanca, University of Salamanca, 37007, Salamanca, Spain

4. Ikerbasque Foundation, 48009, Bilbao, Bizkaia, Spain

5. Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Spain

6. INSERM U1060 CarMeN, Université Claude Bernard Lyon 1 - IRIS team, CarMeN, bat. B13, gpt hosp. Est, 59 bld Pinel, 69500, Bron, Auvergne-Rhône-Alpes, France

7. Department of Women and Children´s Health, Karolisnka Institute, 17164, Stockholm, Södermanland and Uppland, Sweden

8. Department of Neurobiology, University of Massachusetts Medical School, 01605, Worcester, MA, USA

9. Normandie-Univ, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, 14000, Caen, Normandie, France

10. Laboratory of Autophagy, Centro de Investigaciones Biológicas Margarita Salas, Madrid 28040, Spain

11. Department of Medicine, University of Fribourg, 1700, Freiburg, Switzerland

12. Department of Functional Biology, University of Oviedo, 33003, Oviedo, Asturias, Spain

13. Department of Pediatric Oncology, Karolinska University Hospital, 171 64, Stockholm, Södermanland and Uppland, Sweden

14. Department of Pharmacology, University of the Basque Country UPV/EHU, 48940, Leioa, Bizkaia, Spain

Funder

Basque Government

Spanish Ministry of Science and Innovation

Tatiana Foundation

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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