Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux

Author:

Wang Kui1,Zhang Tao2,Lei Yunlong3,Li Xuefeng45,Jiang Jingwen4,Lan Jiang4,Liu Yuan4,Chen Haining6,Gao Wei4,Xie Na4,Chen Qiang4,Zhu Xiaofeng7,Liu Xiang8,Xie Ke9,Peng Yong4,Nice Edouard C.10,Wu Min5,Huang Canhua1,Wei Yuquan4

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China

2. The School of Biomedical Sciences, Chengdu Medical College, Chengdu, China

3. Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China

4. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu,China

5. Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND, USA

6. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China

7. College of Life Science, Sichuan University, Chengdu, China

8. Department of Pathology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China

9. Department of Oncology, Sichuan Provincial People's Hospital, Chengdu, China

10. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

Funder

Chinese NSFC

National 973 Basic Research Program of China

US National Institute of Health

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology

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