Invasive candidiasis: investigational drugs in the clinical development pipeline and mechanisms of action

Author:

Hoenigl Martin123ORCID,Sprute Rosanne456,Arastehfar Amir7,Perfect John R.8,Lass-Flörl Cornelia9,Bellmann Romuald10ORCID,Prattes Juergen14,Thompson George R.11,Wiederhold Nathan P.12,Al Obaidi Mohanad M.13,Willinger Birgit14,Arendrup Maiken C.151617ORCID,Koehler Philipp45ORCID,Oliverio Matteo45,Egger Matthias1,Schwartz Ilan S.18,Cornely Oliver A.45619ORCID,Pappas Peter G.20,Krause Robert1

Affiliation:

1. Division of Infectious Diseases, Excellence Center for Medical Mycology (ECMM), Medical University of Graz, Graz, Austria

2. Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA

3. Working Group, University of California San DiegoClinical and Translational Fungal , La Jolla, CA, USA

4. of Internal Medicine, Excellence Center for Medical Mycology (ECMM)University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I , Cologne, Germany

5. University of Cologne, Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany

6. German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany

7. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA

8. Division of Infectious Diseases and Department of Medicine, Duke University Medical Center, Durham, NC, USA

9. Institute of Hygiene and Medical Microbiology, Excellence Center for Medical Mycology (ECMM), Medical University of Innsbruck, Innsbruck, Austria

10. Clinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

11. Department of Internal Medicine, Division of Infectious Diseases and Department of Medical Microbiology and Immunology, University of California Davis Medical Center, Sacramento, United States

12. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

13. Division of Infectious Diseases, University of Arizona College of Medicine, Tucson, AZ, USA

14. Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

15. Unit of Mycology, Statens Serum Institut, Copenhagen, Denmark

16. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

17. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

18. Division of Infectious Diseases, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada

19. University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany

20. Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA

Funder

No other funding

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Pharmacology,General Medicine

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