1. Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA
2. Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA
3. Department of Statistics, North Carolina State University, Raleigh, NC, USA
4. Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA
5. Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA