Molecular Aspects and Mechanism of Action of Dihydrofolate Reductase Inhibitors

Author:

Hartman P.G.1

Affiliation:

1. F. Hoffmann-La Roche Ltd, Pharma Division, Preclinical Research, CH-4002 Basel, Switzerland.

Publisher

Informa UK Limited

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Oncology

Reference28 articles.

1. Blakley RL. Dihydrofolate reductase. In: Blakley RL, Benkovic SJ, eds. Folates and pteridines, Vol 1. New York: John Wiley, 1984: 191–253.

2. Freisheim JH, Matthews DA. The comparative biochemistry of dihydrofolate reductase. In: Sirotnak FM, Burchall JJ, Ensminger WB, Montgomery JA, eds. Folate antagonists as therapeutic agents, Vol. 1. Orlando: Academic Press, 1984: 70–131.

3. Burchall JJ. Dihydrofolate reductase. In: Hitchings GH, ed. Inhibition of folate metabolism in chemotherapy. Berlin: Springer Verlag, 1983: 55–74.

4. Hitchings GH, Roth B. Dihydrofolate reductases as targets for selective inhibitors. In: Sandler M, ed. Enzyme inhibitors as drugs. London: Macmillan, 1980: 263–280.

5. Burchall JJ. The development of diaminopyrimidines. J Antimicrob Chemother 1979; 5 (Suppl. B): 3–14.

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