Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6 expression in Sprague

Chymotrypsin attenuates adjuvant-induced arthritis by downregulating TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6 expression in Sprague–Dawley rats

Published:2022-07-11 Issue:6 Volume:44 Page:959-969
ISSN:0892-3973
Container-title:Immunopharmacology and Immunotoxicology
language:en
Short-container-title:Immunopharmacology and Immunotoxicology

Author:

Li Jianqiang¹²,Wang Linlin¹²,Zeng Guangting³,Li Huilan¹²,Luo Jia¹²,Tian Qijun⁴,Zhang Zanling¹²

Affiliation:

1. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China

2. Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

3. Department of Pharmacy, The First People’s Hospital of Chenzhou, Xiangnan University, Chenzhou, China

4. Jianqiao Pharmaceutical Limited Liability Company of Hunan Province, Changsha, China

Funder

Hunan Jianqiao Pharmaceutical Co. Ltd of Hunan Province

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/08923973.2022.2093743

Reference47 articles.

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4. MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis

5. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

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