Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

Author:

Witwer Kenneth W.12,Van Balkom Bas W.M.3,Bruno Stefania4,Choo Andre5,Dominici Massimo67,Gimona Mario8,Hill Andrew F.9ORCID,De Kleijn Dominique10,Koh Mickey1112,Lai Ruenn Chai13,Mitsialis S. Alex14,Ortiz Luis A.15,Rohde Eva8,Asada Takashi16,Toh Wei Seong17,Weiss Daniel J.18,Zheng Lei19,Giebel Bernd20,Lim Sai Kiang1321

Affiliation:

1. Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

2. Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

3. Division Internal Medicine and Dermatology, Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands

4. Department of Medical Sciences and Molecular Biotechnology Center, University of Torino, Torino, Italy

5. Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore

6. MAB Laboratory, TPM of Mirandola, Mirandola, Italy

7. Division of Oncology, University of Modena and Reggio Emilia, Modena, Italy

8. GMP Laboratory, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Research Program Nanovesicular Therapies, Department of Transfusion Medicine and Celericon Therapeutics G.m.b.H., Paracelsus Medical University (PMU), Salzburg, Austria

9. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia

10. Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands

11. Department of Haematology, St George’s University Hospital NHS Trust, London, UK

12. Cell Therapy Facility, Blood Services Group Health Sciences Authority, Singapore, Singapore

13. Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore

14. Department of Pediatrics, Harvard Medical School & Division of Newborn Medicine, Boston Children’s Hospital, Boston, MA, USA

15. Division of Environmental and Occupational Medicine, Department of Environmental and Occupational Health, Graduate School of Public Health at the University of Pittsburgh, Pittsburgh, PA, USA

16. Department of Tissue Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

17. Faculty of Dentistry, National University of Singapore, Singapore, Singapore

18. Health Sciences Research Facility, University of Vermont College of Medicine, Burlington, VT, USA

19. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China

20. Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

21. Department of Surgery, YLL School of Medicine, National University of Singapore, Singapore, Singapore

Publisher

Wiley

Subject

Cell Biology,Histology

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