Pitfalls of kinetik modeling of nanoparticles in inhalation studies: new vs. past paradigms
Author:
Affiliation:
1. Bayer Pharma, Toxicology (retired), Wuppertal, Germany
Publisher
Informa UK Limited
Subject
Toxicology,Biomedical Engineering
Link
https://www.tandfonline.com/doi/pdf/10.1080/17435390.2020.1786183
Reference6 articles.
1. Derivation of occupational exposure levels (OELs) of Low-toxicity isometric biopersistent particles: how can the kinetic lung overload paradigm be used for improved inhalation toxicity study design and OEL-derivation?
2. Repeated inhalation exposure of rats to an anionic high molecular weight polymer aerosol: Application of prediction models to better understand pulmonary effects and modes of action
3. Kinetic modeling of the retention and fate of inhaled cerium oxide nanoparticles in rats: The cumulative displacement volume of agglomerates determines the outcome
4. Fate of inhaled Nano-CeO2 revisited: Predicting the unpredictable
5. Schaudien, D., H. Ernst, and S. Rittinghausen. n.d. Histopathological Investigation of Specimens from a Long-Term Inhalation Study (Histopathologische Untersuchung von Proben aus einer Langzeitinhalationsstudie). Rearch project F2325. p.14. https://www.bmu.de/fileadmin/Daten_BMU/Pools/Forschungsdatenbank/fkz_um16_66_203_inhalationstoxizitaet_nano_bf.pdf
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