Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for Alzheimer’s disease

Author:

Li Lily Yi1,Park Elliya1,He Chunsheng1,Abbasi Azhar Z.1,Henderson Jeffrey T.1,Fraser Paul E.2,Uetrecht Jack P.1,Rauth Andrew M.3,Wu Xiao Yu1

Affiliation:

1. Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

2. Tanz Centre for Research in Neurodegenerative Diseases, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

3. Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

Funder

Weston Brain Institute

Natural Sciences and Engineering Research Council of Canada

Canada Council for the Arts

Publisher

Informa UK Limited

Reference78 articles.

1. Systemic Gadolinium Toxicity in Patients With Renal Insufficiency and Renal Failure: Retrospective Analysis of an Initial Experience

2. Russian Roulette with Alzheimer’s Disease Patients: Do the Cognitive Benefits of Lecanemab Outweigh the Risk of Edema, Stroke and Encephalitis??;Atwood C. S.;Journal of Alzheimer’s Disease,2023

3. Australia, D., S. Baker, and S. Banerjee. 2019. Alzheimer’s Disease International World Alzheimer Report 2019: Attitudes to Dementia. London, UK: Alzheimer’s Disease International; Alzheimer’s Disease International.

4. Assessment of Wet Acid Digestion Methods for ICP-MS Determination of Trace Elements in Biological Samples by Using Multivariate Statistical Analysis;Badran M.;Journal of Elementology,2018

5. Drug dosing in obese adults

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