1. Department of General and Internal Medicine, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
2. Department of Rheumatology, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
3. Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Nagasaki, Japan;
4. Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
5. Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
6. Department of Pathology, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan;
7. Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan