Identification and characterization of amiodarone metabolites in rats using UPLC–ESI-QTOFMS-based untargeted metabolomics approach
Author:
Affiliation:
1. Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Korea
2. Korea Institute of Toxicology, Yuseong-gu, Daejeon, Korea
Funder
the National Reserch Foundation of Korea
the National Research Foundation of Korea
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Toxicology
Link
https://www.tandfonline.com/doi/pdf/10.1080/15287394.2018.1460783
Reference25 articles.
1. Identification of Amiodarone Metabolites in Human Bile by Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
2. The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole
3. Stimulation of Human Monocytic THP-1 Cells by Metabolic Activation of Hepatotoxic Drugs
4. LC–MS-based metabolomics: an update
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