Lesions in the anterior thalamic nuclei of rats do not disrupt acquisition of stimulus sequence learning

Author:

Aggleton John P.1,Amin Eman1,Jenkins Trisha A.2,Pearce John M.1,Robinson Jasper3

Affiliation:

1. Cardiff University, Cardiff, UK

2. Discipline of Pharmaceutical Sciences, School of Medical Science, RMIT University, Melbourne, Victoria, Australia

3. University of Nottingham, Nottingham, UK

Abstract

Sequence learning and spatial alternation were examined in rats with anterior thalamic lesions or sham surgeries. There was a lesion-induced deficit in spatial alternation but not in sequence learning. During sequence learning, rats discriminated between six different sequentially presented compounds (e.g., reinforce A before B, but not B before A), composed of audio-visual elements. The solution required rats to learn both specific stimulus sequences and the reward contingencies associated with these specific temporal relationships. The failure of anterior thalamic lesions to affect the acquisition of this sequential configural task complements the recent finding that anterior thalamic lesions also spare the acquisition of a configural task involving specific stimulus pairings and their spatial relationships. These findings suggest that such “structural” learning is more reliant on cortico-hippocampal than thalamo-hippocampal interactions.

Publisher

SAGE Publications

Subject

Physiology (medical),General Psychology,Experimental and Cognitive Psychology,General Medicine,Neuropsychology and Physiological Psychology,Physiology

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