Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies

Author:

Motzer Robert J.1,Taylor Matthew H.2,Evans Thomas R. Jeffry34,Okusaka Takuji5,Glen Hilary4,Lubiniecki Gregory M.6,Dutcus Corina7,Smith Alan D.7,Okpara Chinyere E.7,Hussein Ziad8,Hayato Seiichi9,Tamai Toshiyuki10,Makker Vicky1

Affiliation:

1. Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, NY, USA

2. Division of Hematology and Oncology, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, USA

3. Institute of Cancer Sciences, University of Glasgow, Glasgow, UK

4. Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK

5. Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan

6. Global Clinical Development, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA

7. Clinical Research, Eisai Inc., Nutley, NJ, USA

8. Clinical Pharmacology Science, Eisai Europe Ltd, Hatfield, UK

9. Clinical Pharmacology Science, Eisai Co., Ltd, Tokyo, Japan

10. Clinical Research, Eisai Co., Ltd, Tokyo, Japan

Funder

Eisai Inc., Nutley, NJ, USA, and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. R.M. and V.M

Swati Khare, PhD, of Oxford PharmaGenesis Inc., Newtown, PA, USA

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Oncology

Reference83 articles.

1. Lenvatinib

2. Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer

3. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

4. Eisai Co., Ltd., MSK K.K. Lenvima® (lenvatinib) approved for additional indication of unresectable thymic carcinoma in Japan [press release]. Mar 23. Available at: https://www.eisai.com/news/2021/news202120.html [Accessed December 17, 2021].

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