Utilizing postmortem drug concentrations in mechanistic modeling and simulation of cardiac effects: a proof of concept study with methadone-Reference-Cited by-同舟云学术

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Utilizing postmortem drug concentrations in mechanistic modeling and simulation of cardiac effects: a proof of concept study with methadone

Published:2018-06-13 Issue:8 Volume:28 Page:555-562
ISSN:1537-6516
Container-title:Toxicology Mechanisms and Methods
language:en
Short-container-title:Toxicology Mechanisms and Methods

Author:

Mikkelsen Christian Reuss¹^ORCID,Jornil Jakob Ross¹,Andersen Ljubica Vukelic¹,Hasselstrøm Jørgen Bo¹,Polak Sebastian²³

Affiliation:

1. Section of Forensic Chemistry, Department of Forensic Medicine, Aarhus University, Aarhus, Denmark;

2. Department of Social Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland;

3. Simcyp Division, Certara UK, Sheffield, UK

Funder

Aarhus University

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15376516.2018.1475537

Reference48 articles.

1. Methadone-related deaths in Norway

2. A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study

3. CiPA: Ongoing testing, future qualification procedures, and pending issues

4. Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias

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1. A computational analysis of the effect of sevoflurane in a human ventricular cell model of long QT syndrome: Importance of repolarization reserve in the QT-prolonging effect of sevoflurane;European Journal of Pharmacology;2020-09

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