Effects of 2-amino-9H-pyrido[2,3-b]indole (AαC) metabolic bio-activation on oxidative DNA damage in human hepatoma G2 (HepG2) cells
Author:
Affiliation:
1. Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China;
2. Technology Center of Henan Tobacco Industrial Co., Ltd, Zhengzhou, China
Funder
National Natural Science Foundation of China
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Toxicology
Link
https://www.tandfonline.com/doi/pdf/10.1080/15376516.2017.1391363
Reference39 articles.
1. Factors That Affect the Content of Heterocyclic Aromatic Amines in Foods
2. Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes
3. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
4. Genotoxicity of 10 cigarette smoke condensates in four test systems: Comparisons between assays and condensates
5. Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells
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