1. Department of Family and Community Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
2. Medicines Evaluation Unit, Manchester University NHS Foundations Trust, University of Manchester, Manchester, UK
3. Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina Pulmonary Critical Medicine, Chapel Hill, NC, USA
4. Asthma and Airway Center, University Health Network, Toronto, ON, Canada
5. School of Medicine, Johns Hopkins University, Baltimore, MD, USA