1. Department of Anaesthesia, Intensive Care and Pain Medicine, Mater Dei Hospital, Triq Dun Karm, Malta
2. Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida MSD, Malta
3. Fondazione Ricerca e Salute (ReS)-Research and Health Foundation, Casalecchio di Reno, Italy
4. Exeter College of Medicine and Health, University of Exeter, Exeter, UK