Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase-Reference-Cited by-同舟云学术

Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase

Published:2017-11-08 Issue:1 Volume:33 Page:74-84
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Kurup Sonali¹,McAllister Bradley¹,Liskova Pavlina¹,Mistry Trusha¹,Fanizza Anthony²,Stanford Dan²,Slawska Jolanta³,Keller Ulrich³⁴,Hoellein Alexander³

Affiliation:

1. College of Pharmacy, Roosevelt University, Schaumburg, IL, USA;

2. Department of Chemistry, Harper College, Palatine, IL, USA;

3. III. Medical Department, Technische Universität München, Munich, Germany;

4. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

Funder

Roosevelt University

German Cancer Research Center

Deutsche Forschungsgemeinschaft

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://tandfonline.com/doi/pdf/10.1080/14756366.2017.1376666

Reference25 articles.

1. Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors

2. Drugs to Treat Head and Neck Cancers: Mechanisms of Action

3. Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer

4. The quest to overcome resistance to EGFR-targeted therapies in cancer

5. Aurora kinases in head and neck cancer

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