Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions
Author:
Affiliation:
1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
Funder
Medical and Health Innovation Project of Chinese Academy of Medical Sciences
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/14756366.2019.1702653
Reference23 articles.
1. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
2. RAS oncogenes: the first 30 years
3. Ras in Cancer and Developmental Diseases
4. A Comprehensive Survey of Ras Mutations in Cancer
5. Functional Specificity of Ras Isoforms: So Similar but So Different
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