Predicting potentially pathogenic effects of <i>h</i>RPE65 missense mutations: a computational strategy based on molecular dynamics simulations-Reference-Cited by-同舟云学术

Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations

Published:2022-06-21 Issue:1 Volume:37 Page:1765-1772
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Poli Giulio¹^ORCID,Barravecchia Ivana¹²,Demontis Gian Carlo¹^ORCID,Sodi Andrea³,Saba Alessandro⁴^ORCID,Rizzo Stanislao⁵⁶⁷^ORCID,Macchia Marco¹,Tuccinardi Tiziano¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Pisa, Pisa, Italy

2. Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy

3. Department of Neurosciences, Psychology, Drug Research and Child Health Eye Clinic, University of Florence, AOU Careggi, Florence, Italy

4. Department of Surgical Pathology, Molecular Medicine and of the Critical Area, University of Pisa, Pisa, Italy

5. Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

6. Catholic University Sacro Cuore, Rome, Italy

7. Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Pisa, Italy

Funder

Novartis Farma Italy and Novartis Pharma AG

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2090547

Reference30 articles.

1. Potential Therapeutic Agents Against Retinal Diseases Caused by Aberrant Metabolism of Retinoids

2. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor

3. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

4. Retinyl Esters Are the Substrate for Isomerohydrolase

5. Retinal pigment epithelium 65 kDa protein (RPE65): An update

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